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pentobarbital will minimize the level or impact of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will lessen the level or effect of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital increases toxicity of methoxyflurane by increasing metabo